Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC4826398 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Wang Jiyong J Cohen Allison L AL Letian Anudari A Tadeo Xavier X Moresco James J JJ Liu Jinqiang J Yates John R JR Qiao Feng F Jia Songtao S
Genes & development 20160317 7
Telomeric regions contain prominent sites of heterochromatin, which is associated with unique histone modification profiles such as the methylation of histone H3 at Lys9 (H3K9me). In fission yeast, the conserved telomeric shelterin complex recruits the histone H3K9 methyltransferase complex CLRC to establish subtelomeric heterochromatin. Although many shelterin mutations affect subtelomeric heterochromatin assembly, the mechanism remains elusive due to the diverse functions of shelterin. Through ...[more]