Ontology highlight
ABSTRACT:
SUBMITTER: Abeysekera I
PROVIDER: S-EPMC4828301 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Abeysekera Irushi I Thomas Jared J Georgiadis Taxiarchis M TM Berman Alycia G AG Hammond Max A MA Dria Karl J KJ Wallace Joseph M JM Roper Randall J RJ
Molecular nutrition & food research 20160211 4
<h4>Scope</h4>Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is characterized by a spectrum of phenotypes including skeletal abnormalities. The Ts65Dn DS mouse model exhibits similar skeletal phenotypes as humans with DS. DYRK1A, a kinase encoded on Hsa21, has been linked to deficiencies in bone homeostasis in DS mice and individuals with DS. Treatment with Epigallocatechin-3-gallate (EGCG), a known inhibitor of Dyrk1a, improves some skeletal abnormalities associated with ...[more]