Ontology highlight
ABSTRACT:
SUBMITTER: Izzo V
PROVIDER: S-EPMC5323035 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Izzo Valentina V Pietrocola Federico F Sica Valentina V Durand Sylvère S Lachkar Sylvie S Enot David D Bravo-San Pedro José Manuel JM Chery Alexis A Esposito Speranza S Raia Valeria V Maiuri Luigi L Maiuri Maria Chiara MC Kroemer Guido G
Cell cycle (Georgetown, Tex.) 20170106 3
Phase II clinical trials indicate that the combination of cysteamine plus epigallocatechin gallate (EGCG) is effective against cystic fibrosis in patients bearing the most frequent etiological mutation (CFTRΔF508). Here, we investigated the interaction between both agents on cultured respiratory epithelia cells from normal and CFTRΔF508-mutated donors. We observed that the combination of both agents affected metabolic circuits (and in particular the tricarboxylic acid cycle) in a unique way and ...[more]