Ontology highlight
ABSTRACT:
SUBMITTER: Padmanabhan A
PROVIDER: S-EPMC4828729 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Padmanabhan Achuth A Vuong Simone Anh-Thu SA Hochstrasser Mark M
Cell reports 20160322 12
Targeted intracellular protein degradation in eukaryotes is largely mediated by the proteasome. Here, we report the formation of an alternative proteasome isoform in human cells, previously found only in budding yeast, that bears an altered subunit arrangement in the outer ring of the proteasome core particle. These proteasomes result from incorporation of an additional α4 (PSMA7) subunit in the position normally occupied by α3 (PSMA4). Assembly of "α4-α4" proteasomes depends on the relative cel ...[more]