Ontology highlight
ABSTRACT:
SUBMITTER: Rousseau A
PROVIDER: S-EPMC4990136 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Nature 20160727 7615
The proteasome is essential for the selective degradation of most cellular proteins, but how cells maintain adequate amounts of proteasome is unclear. Here we show that there is an evolutionarily conserved signalling pathway controlling proteasome homeostasis. Central to this pathway is TORC1, the inhibition of which induced all known yeast 19S regulatory particle assembly-chaperones (RACs), as well as proteasome subunits. Downstream of TORC1 inhibition, the yeast mitogen-activated protein kinas ...[more]