Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC4828960 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Wang Jennie J Liu Mingtao M Yang Chun C Wu Xiaogang X Wang Euphemia E Liu Paul P
Journal of pharmaceutical and biomedical analysis 20160227
An HPLC method for the assay of a DNA topoisomerase inhibitor, LMP776 (NSC 725776), has been developed and validated. The stress testing of LMP776 was carried out in accordance with International Conference on Harmonization (ICH) guidelines Q1A (R2) under acidic, alkaline, oxidative, thermolytic, and photolytic conditions. The separation of LMP776 from its impurities and degradation products was achieved within 40 min on a Supelco Discovery HS F5 column (150 mm × 4.6 mm i.d., 5 μm) with a gradie ...[more]