Ontology highlight
ABSTRACT:
SUBMITTER: Muzzio M
PROVIDER: S-EPMC4420695 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Muzzio Miguel M Hu Shu-Chieh SC Holleran Julianne L JL Parise Robert A RA Eiseman Julie L JL Yellow-Duke Archibong E AE Covey Joseph M JM Glaze Elizabeth R ER Engelke Kory K Egorin Merrill J MJ McCormick David L DL Beumer Jan H JH
Cancer chemotherapy and pharmacology 20150317 5
<h4>Purpose</h4>NSC 743400 is a novel synthetic indenoisoquinoline analog under development as an anticancer agent. It is a potent topoisomerase I inhibitor with potential therapeutic advantages over FDA-approved camptothecin derivatives. In preparation for clinical development of NSC 743400, we determined the pharmacokinetics after administration to rats and dogs.<h4>Methods</h4>NSC 743400 was administered intravenously at a dose of 12 or 24 mg/m(2) to rats (single bolus) or 10, 50, 100, 215, 4 ...[more]