Ontology highlight
ABSTRACT:
SUBMITTER: Stratmann SA
PROVIDER: S-EPMC4829420 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Stratmann Sarah A SA Morrone Seamus R SR van Oijen Antoine M AM Sohn Jungsan J
eLife 20151216
The ability to recognize foreign double-stranded (ds)DNA of pathogenic origin in the intracellular environment is an essential defense mechanism of the human innate immune system. However, the molecular mechanisms underlying distinction between foreign DNA and host genomic material inside the nucleus are not understood. By combining biochemical assays and single-molecule techniques, we show that the nuclear innate immune sensor IFI16 one-dimensionally tracks long stretches of exposed foreign dsD ...[more]