Ontology highlight
ABSTRACT:
SUBMITTER: Phoenix TN
PROVIDER: S-EPMC4829447 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Cancer cell 20160331 4
The childhood brain tumor, medulloblastoma, includes four subtypes with very different prognoses. Here, we show that paracrine signals driven by mutant β-catenin in WNT-medulloblastoma, an essentially curable form of the disease, induce an aberrant fenestrated vasculature that permits the accumulation of high levels of intra-tumoral chemotherapy and a robust therapeutic response. In contrast, SHH-medulloblastoma, a less curable disease subtype, contains an intact blood brain barrier, rendering t ...[more]