Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis.
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ABSTRACT:
SUBMITTER: Mirsaeidi M
PROVIDER: S-EPMC4830063 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis.
Mirsaeidi Mehdi M Gidfar Sanaz S Vu Ann A Schraufnagel Dean D
Journal of translational medicine 20160412
Annexins are Ca(2+)-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression ...[more]
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