Ontology highlight
ABSTRACT:
SUBMITTER: Schmitt AM
PROVIDER: S-EPMC4831138 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveyi ...[more]