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Benralizumab: a unique IL-5 inhibitor for severe asthma.


ABSTRACT: The presence of eosinophilic inflammation is a characteristic feature of chronic and acute inflammation in asthma. An estimated 5%-10% of the 300 million people worldwide who suffer from asthma have a severe form. Patients with eosinophilic airway inflammation represent approximately 40%-60% of this severe asthmatic population. This form of asthma is often uncontrolled, marked by refractoriness to standard therapy, and shows persistent airway eosinophilia despite glucocorticoid therapy. This paper reviews personalized novel therapies, more specifically benralizumab, a humanized anti-IL-5R? antibody, while also being the first to provide an algorithm for potential candidates who may benefit from anti-IL-5R? therapy.

SUBMITTER: Tan LD 

PROVIDER: S-EPMC4831605 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Benralizumab: a unique IL-5 inhibitor for severe asthma.

Tan Laren D LD   Bratt Jennifer M JM   Godor Dorottya D   Louie Samuel S   Kenyon Nicholas J NJ  

Journal of asthma and allergy 20160404


The presence of eosinophilic inflammation is a characteristic feature of chronic and acute inflammation in asthma. An estimated 5%-10% of the 300 million people worldwide who suffer from asthma have a severe form. Patients with eosinophilic airway inflammation represent approximately 40%-60% of this severe asthmatic population. This form of asthma is often uncontrolled, marked by refractoriness to standard therapy, and shows persistent airway eosinophilia despite glucocorticoid therapy. This pap  ...[more]

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