The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia.
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ABSTRACT:
SUBMITTER: Bastian BC
PROVIDER: S-EPMC4831647 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia.
Annual review of pathology 20140101
Melanomas comprise multiple biologically distinct categories, which differ in cell of origin, age of onset, clinical and histologic presentation, pattern of metastasis, ethnic distribution, causative role of UV radiation, predisposing germ-line alterations, mutational processes, and patterns of somatic mutations. Neoplasms are initiated by gain-of-function mutations in one of several primary oncogenes, which typically lead to benign melanocytic nevi with characteristic histologic features. The p ...[more]
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