Genetic Variants Associated with Colorectal Adenoma Susceptibility.

ABSTRACT:

Background

Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk.

Aim

To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas).

Methods

We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity.

Results

We found t

SUBMITTER: Abuli A 

PROVIDER: S-EPMC4831735 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature