Ontology highlight
ABSTRACT:
SUBMITTER: Tegtmeyer N
PROVIDER: S-EPMC4832355 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Tegtmeyer Nicole N Moodley Yoshan Y Yamaoka Yoshio Y Pernitzsch Sandy Ramona SR Schmidt Vanessa V Traverso Francisco Rivas FR Schmidt Thomas P TP Rad Roland R Yeoh Khay Guan KG Bow Ho H Torres Javier J Gerhard Markus M Schneider Gisbert G Wessler Silja S Backert Steffen S
Molecular microbiology 20151222 5
HtrA proteases and chaperones exhibit important roles in periplasmic protein quality control and stress responses. The genetic inactivation of htrA has been described for many bacterial pathogens. However, in some cases such as the gastric pathogen Helicobacter pylori, HtrA is secreted where it cleaves the tumour-suppressor E-cadherin interfering with gastric disease development, but the generation of htrA mutants is still lacking. Here, we show that the htrA gene locus is highly conserved in wo ...[more]