Dataset Information

Membrane substrates of HtrA from Helicobacter pylori

ABSTRACT: High temperature requirement A (HtrA) is a serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expressed on the surface of gastric epithelial cells was identified as the first HtrA substrate. HtrA-mediated hCdh1 cleavage and subsequent disruption of intercellular adhesion are considered as important steps in H. pylori pathogenesis. In this study, we performed a proteomic profiling of H. pylori HtrA (HpHtrA) to decipher the complex mechanism how H. pylori can interfere with epithelial barrier integrity.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Marko Fonovic

LAB HEAD: Marko Fonovic

PROVIDER: PXD025360 | Pride | 2022-02-17

REPOSITORIES: Pride

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Publications

Identification of Desmoglein-2 as a novel target of Helicobacter pylori HtrA in epithelial cells.

Bernegger Sabine S Vidmar Robert R Fonovic Marko M Posselt Gernot G Turk Boris B Wessler Silja S

Cell communication and signaling : CCS 20211106 1

<h4>Background</h4>High temperature requirement A (HtrA) is an active serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expressed on the surface of gastric epithelial cells was identified as the first HtrA substrate. HtrA-mediated hCdh1 cleavage and subsequent disruption of intercellular adhesions are considered as important steps in H. pylori pathogenesis. In this study, we performed a prot ...[more]

PMID: 34742300

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