Ontology highlight
ABSTRACT:
SUBMITTER: Euesden J
PROVIDER: S-EPMC4833173 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Euesden Jack J Breen Gerome G Farmer Anne A McGuffin Peter P Lewis Cathryn M CM
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20150205 2
Epidemiological studies are inconsistent on the relationship between schizophrenia (SCZ) and rheumatoid arthritis (RA). Several studies have shown that SCZ has a protective effect on RA, with RA occurring less frequently in SCZ cases than would be expected by chance, whilst other studies have failed to replicate this. We sought to test the hypothesis that this effect is due to a protective effect of SCZ risk alleles on RA onset. We first reviewed the literature on the comorbidity of RA and SCZ a ...[more]