Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC4833211 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Wang Shizhen S Vafabakhsh Reza R Borschel William F WF Ha Taekjip T Nichols Colin G CG
Nature structural & molecular biology 20151207 1
Crystallography has provided invaluable insights regarding ion-channel selectivity and gating, but to advance understanding to a new level, dynamic views of channel structures within membranes are essential. We labeled tetrameric KirBac1.1 potassium channels with single donor and acceptor fluorophores at different sites and then examined structural dynamics within lipid membranes by single-molecule fluorescence resonance energy transfer (FRET). We found that the extracellular region is structura ...[more]