Ontology highlight
ABSTRACT:
SUBMITTER: Lin CW
PROVIDER: S-EPMC5543805 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Lin Chun-Wei CW Mensa Bruk B Barniol-Xicota Marta M DeGrado William F WF Gai Feng F
Angewandte Chemie (International ed. in English) 20170404 19
Because of its importance in viral replication, the M2 proton channel of the influenza A virus has been the focus of many studies. Although we now know a great deal about the structural architecture underlying its proton conduction function, we know little about its conformational dynamics, especially those controlling the rate of this action. Herein, we employ a single-molecule fluorescence method to assess the dynamics of the inter-helical channel motion of both full-length M2 and the transmem ...[more]