Highly sensitive and ultrafast read mapping for RNA-seq analysis.
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ABSTRACT:
SUBMITTER: Medina I
PROVIDER: S-EPMC4833417 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Highly sensitive and ultrafast read mapping for RNA-seq analysis.
Medina I I Tárraga J J Martínez H H Barrachina S S Castillo M I MI Paschall J J Salavert-Torres J J Blanquer-Espert I I Hernández-García V V Quintana-Ortí E S ES Dopazo J J
DNA research : an international journal for rapid publication of reports on genes and genomes 20160105 2
As sequencing technologies progress, the amount of data produced grows exponentially, shifting the bottleneck of discovery towards the data analysis phase. In particular, currently available mapping solutions for RNA-seq leave room for improvement in terms of sensitivity and performance, hindering an efficient analysis of transcriptomes by massive sequencing. Here, we present an innovative approach that combines re-engineering, optimization and parallelization. This solution results in a signifi ...[more]
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