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HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy.


ABSTRACT: Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.

SUBMITTER: Janeckova L 

PROVIDER: S-EPMC4833890 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy.

Janeckova Lucie L   Kolar Michal M   Svec Jiri J   Lanikova Lucie L   Pospichalova Vendula V   Baloghova Nikol N   Vojtechova Martina M   Sloncova Eva E   Strnad Hynek H   Korinek Vladimir V  

Translational oncology 20160304 2


Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specifi  ...[more]

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