Ontology highlight
ABSTRACT:
SUBMITTER: Janeckova L
PROVIDER: S-EPMC4833890 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Janeckova Lucie L Kolar Michal M Svec Jiri J Lanikova Lucie L Pospichalova Vendula V Baloghova Nikol N Vojtechova Martina M Sloncova Eva E Strnad Hynek H Korinek Vladimir V
Translational oncology 20160304 2
Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specifi ...[more]