Ontology highlight
ABSTRACT:
SUBMITTER: Alme AK
PROVIDER: S-EPMC4834698 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Urologic oncology 20160228 4
Despite a long history of immunotherapeutic approaches to treatment, most genitourinary malignancies are not cured by existing immunotherapy regimens. More recently, cell surface molecules known as immune checkpoints have become the focus of efforts to develop more effective immunotherapies. Interactions between these molecules and their ligands inhibit the proliferation and function of tumor-specific lymphocytes. A monoclonal antibody blocking 1 of these checkpoints was approved for the treatme ...[more]