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Total Synthesis of Cryptocaryol A by Enantioselective Iridium-Catalyzed Alcohol C-H Allylation.

ABSTRACT: The polyketide natural product cryptocaryol?A is prepared in 8 steps via iridium catalyzed enantioselective diol double C-H allylation, which directly generates an acetate-based triketide stereodiad. In 4 previously reported total syntheses, 17-28 steps were required.

SUBMITTER: Perez F 

PROVIDER: S-EPMC4834877 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Total Synthesis of Cryptocaryol A by Enantioselective Iridium-Catalyzed Alcohol C-H Allylation.

Perez Felix F   Waldeck Andrew R AR   Krische Michael J MJ  

Angewandte Chemie (International ed. in English) 20160311 16

The polyketide natural product cryptocaryol A is prepared in 8 steps via iridium catalyzed enantioselective diol double C-H allylation, which directly generates an acetate-based triketide stereodiad. In 4 previously reported total syntheses, 17-28 steps were required. ...[more]

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