Ontology highlight
ABSTRACT:
SUBMITTER: Grecka E
PROVIDER: S-EPMC4835110 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Grecka Emilia E Statkiewicz Malgorzata M Gorska Agnieszka A Biernacka Marzena M Grygorowicz Monika Anna MA Masnyk Marek M Chmielewski Marek M Gawarecka Katarzyna K Chojnacki Tadeusz T Swiezewska Ewa E Malecki Maciej M
PloS one 20160418 4
<h4>Purpose</h4>Prenyl ammonium iodides (Amino-Prenols, APs), semi-synthetic polyprenol derivatives were studied as prospective novel gene transfer agents.<h4>Methods</h4>AP-7, -8, -11 and -15 (aminoprenols composed of 7, 8, 11 or 15 isoprene units, respectively) were examined for their capacity to form complexes with pDNA, for cytotoxicity and ability to transfect genes to cells.<h4>Results</h4>All the carriers were able to complex DNA. The highest, comparable to commercial reagents, transfecti ...[more]