Ontology highlight
ABSTRACT:
SUBMITTER: Chen M
PROVIDER: S-EPMC4836026 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Chen Ming M Chen Ziheng Z Wang Yueying Y Tan Zheng Z Zhu Chongzhuo C Li Yanjun Y Han Zhe Z Chen Linbo L Gao Ruize R Liu Lei L Chen Quan Q
Autophagy 20160101 4
Mitochondrial fragmentation due to imbalanced fission and fusion of mitochondria is a prerequisite for mitophagy, however, the exact "coupling" of mitochondrial dynamics and mitophagy remains unclear. We have previously identified that FUNDC1 recruits MAP1LC3B/LC3B (LC3) through its LC3-interacting region (LIR) motif to initiate mitophagy in mammalian cells. Here, we show that FUNDC1 interacts with both DNM1L/DRP1 and OPA1 to coordinate mitochondrial fission or fusion and mitophagy. OPA1 interac ...[more]