Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC7484983 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Li Jie J Agarwal Ekta E Bertolini Irene I Seo Jae Ho JH Caino M Cecilia MC Ghosh Jagadish C JC Kossenkov Andrew V AV Liu Qin Q Tang Hsin-Yao HY Goldman Aaron R AR Languino Lucia R LR Speicher David W DW Altieri Dario C DC
Science signaling 20200728 642
Mitochondria are signaling hubs in eukaryotic cells. Here, we showed that the mitochondrial FUN14 domain-containing protein-1 (FUNDC1), an effector of Parkin-independent mitophagy, also participates in cellular plasticity by sustaining oxidative bioenergetics, buffering ROS production, and supporting cell proliferation. Targeting this pathway in cancer cells suppressed tumor growth but rendered transformed cells more motile and invasive in a manner dependent on ROS-mediated mitochondrial dynamic ...[more]