The emerging role of GATA transcription factors in development and disease.
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ABSTRACT:
SUBMITTER: Lentjes MH
PROVIDER: S-EPMC4836206 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
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The emerging role of GATA transcription factors in development and disease.
Lentjes Marjolein H F M MH Niessen Hanneke E C HE Akiyama Yoshimitsu Y de Bruïne Adriaan P AP Melotte Veerle V van Engeland Manon M
Expert reviews in molecular medicine 20160308
The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance ...[more]
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