Ontology highlight
ABSTRACT:
SUBMITTER: Stathopoulou K
PROVIDER: S-EPMC4836368 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Stathopoulou Konstantina K Wittig Ilka I Heidler Juliana J Piasecki Angelika A Richter Florian F Diering Simon S van der Velden Jolanda J Buck Friedrich F Donzelli Sonia S Schröder Ewald E Wijnker Paul J M PJ Voigt Niels N Dobrev Dobromir D Sadayappan Sakthivel S Eschenhagen Thomas T Carrier Lucie L Eaton Philip P Cuello Friederike F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20160202 5
Cardiac myosin-binding protein C (cMyBP-C) regulates actin-myosin interaction and thereby cardiac myocyte contraction and relaxation. This physiologic function is regulated by cMyBP-C phosphorylation. In our study, reduced site-specific cMyBP-C phosphorylation coincided with increased S-glutathiolation in ventricular tissue from patients with dilated or ischemic cardiomyopathy compared to nonfailing donors. We used redox proteomics, to identify constitutive and disease-specific S-glutathiolation ...[more]