Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.
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ABSTRACT:
SUBMITTER: Lee BW
PROVIDER: S-EPMC4836958 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.
Lee Benjamin W BW Liu Bohao B Pluchinsky Adam A Kim Nathan N Eng George G Vunjak-Novakovic Gordana G
Advanced healthcare materials 20160210 8
This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites contract synchronously, facilitating the use of this tissue-engineering platform to study structure-function rel ...[more]
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