Ontology highlight
ABSTRACT:
SUBMITTER: Deans RM
PROVIDER: S-EPMC4836973 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Deans Richard M RM Morgens David W DW Ökesli Ayşe A Pillay Sirika S Horlbeck Max A MA Kampmann Martin M Gilbert Luke A LA Li Amy A Mateo Roberto R Smith Mark M Glenn Jeffrey S JS Carette Jan E JE Khosla Chaitan C Bassik Michael C MC
Nature chemical biology 20160328 5
Broad-spectrum antiviral drugs targeting host processes could potentially treat a wide range of viruses while reducing the likelihood of emergent resistance. Despite great promise as therapeutics, such drugs remain largely elusive. Here we used parallel genome-wide high-coverage short hairpin RNA (shRNA) and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 screens to identify the cellular target and mechanism of action of GSK983, a potent broad-spectrum antiviral with unex ...[more]