Novel antioxidants protect mitochondria from the effects of oligomeric amyloid beta and contribute to the maintenance of epigenome function.
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ABSTRACT:
SUBMITTER: Mastroeni D
PROVIDER: S-EPMC4838453 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
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Novel antioxidants protect mitochondria from the effects of oligomeric amyloid beta and contribute to the maintenance of epigenome function.
Mastroeni Diego D Khdour Omar M OM Arce Pablo M PM Hecht Sidney M SM Coleman Paul D PD
ACS chemical neuroscience 20150224 4
Alzheimer's disease is associated with metabolic deficits and reduced mitochondrial function, with the latter due to the effects of oligomeric amyloid beta peptide (AβO) on the respiratory chain. Recent evidence has demonstrated reduction of epigenetic markers, such as DNA methylation, in Alzheimer's disease. Here we demonstrate a link between metabolic and epigenetic deficits via reduction of mitochondrial function which alters the expression of mediators of epigenetic modifications. AβO-induce ...[more]
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