Ontology highlight
ABSTRACT:
SUBMITTER: Markley JL
PROVIDER: S-EPMC4840021 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20160121 3
A phosphate tether-mediated ring-closing metathesis (RCM) study to the synthesis of Z-configured, P-stereogenic bicyclo[7.3.1]- and bicyclo[8.3.1]phosphates is reported. Investigations suggest that C3-substitution, olefin substitution, and proximity of the forming olefin to the bridgehead carbon of the bicyclic affect the efficiency and stereochemical outcome of the RCM event. This study demonstrates the utility of phosphate tether-mediated desymmetrization of C2-symmetric, 1,3-anti-diol-contain ...[more]