Ontology highlight
ABSTRACT:
SUBMITTER: Jang S
PROVIDER: S-EPMC4840048 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Neuron 20160407 2
Changes in neuronal activity create local and transient changes in energy demands at synapses. Here we discover a metabolic compartment that forms in vivo near synapses to meet local energy demands and support synaptic function in Caenorhabditis elegans neurons. Under conditions of energy stress, glycolytic enzymes redistribute from a diffuse localization in the cytoplasm to a punctate localization adjacent to synapses. Glycolytic enzymes colocalize, suggesting the ad hoc formation of a glycolys ...[more]