Ontology highlight
ABSTRACT:
SUBMITTER: Jin M
PROVIDER: S-EPMC5586494 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Cell reports 20170701 4
Glycolysis is upregulated under conditions such as hypoxia and high energy demand to promote cell proliferation, although the mechanism remains poorly understood. We find that hypoxia in Saccharomyces cerevisiae induces concentration of glycolytic enzymes, including the Pfk2p subunit of the rate-limiting phosphofructokinase, into a single, non-membrane-bound granule termed the "glycolytic body" or "G body." A yeast kinome screen identifies the yeast ortholog of AMP-activated protein kinase, Snf1 ...[more]