Ontology highlight
ABSTRACT:
SUBMITTER: Carney B
PROVIDER: S-EPMC4841747 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Carney Brandon B Carlucci Giuseppe G Salinas Beatriz B Di Gialleonardo Valentina V Kossatz Susanne S Vansteene Axel A Longo Valerie A VA Bolaender Alexander A Chiosis Gabriela G Keshari Kayvan R KR Weber Wolfgang A WA Reiner Thomas T
Molecular imaging and biology 20160601 3
<h4>Purpose</h4>The current study presents [(18)F]PARPi as imaging agent for PARP1 expression.<h4>Procedures</h4>[(18)F]PARPi was generated by conjugating a 2H-phthalazin-1-one scaffold to 4-[(18)F]fluorobenzoic acid. Biochemical assays, optical in vivo competition, biodistribution analysis, positron emission tomography (PET)/X-ray computed tomography, and PET/magnetic resonance imaging studies were performed in subcutaneous and orthotopic mouse models of glioblastoma.<h4>Results</h4>[(18)F]PARP ...[more]