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Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma.

ABSTRACT: PURPOSE:The current study presents [(18)F]PARPi-FL as a bimodal fluorescent/positron emission tomography (PET) agent for PARP1 imaging. PROCEDURES:[(18)F]PARPi-FL was obtained by (19)F/(18)F isotopic exchange and PET experiments, biodistribution studies, surface fluorescence imaging, and autoradiography carried out in a U87 MG glioblastoma mouse model. RESULTS:[(18)F]PARPi-FL showed high tumor uptake in vivo and ex vivo in small xenografts (

SUBMITTER: Carlucci G

PROVIDER: S-EPMC4609241 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Dual-Modality Optical/PET Imaging of PARP1 in Glioblastoma.

Carlucci Giuseppe G Carney Brandon B Brand Christian C Kossatz Susanne S Irwin Christopher P CP Carlin Sean D SD Keliher Edmund J EJ Weber Wolfgang W Reiner Thomas T

Molecular imaging and biology 20151201 6

<h4>Purpose</h4>The current study presents [(18)F]PARPi-FL as a bimodal fluorescent/positron emission tomography (PET) agent for PARP1 imaging.<h4>Procedures</h4>[(18)F]PARPi-FL was obtained by (19)F/(18)F isotopic exchange and PET experiments, biodistribution studies, surface fluorescence imaging, and autoradiography carried out in a U87 MG glioblastoma mouse model.<h4>Results</h4>[(18)F]PARPi-FL showed high tumor uptake in vivo and ex vivo in small xenografts (< 2 mm) with both PET and optical ...[more]

PMID: 25895168

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