Ontology highlight
ABSTRACT:
SUBMITTER: Yoshimoto FK
PROVIDER: S-EPMC4841756 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Yoshimoto Francis K FK Auchus Richard J RJ
The Journal of steroid biochemistry and molecular biology 20151022
All cytochrome P450 enzyme reactions involve a catalytic cycle with several discreet physical or chemical steps. This cycle ends with the formation of the reactive heme iron-oxygen complex, which oxygenates substrate. While the steps might be very similar for each P450 enzyme, the rates of each step varies tremendously for each enzyme and sometimes even for different reactions catalyzed by the same enzyme. For example, the rate-limiting step for most bacterial P450 enzymes, with turnover numbers ...[more]