Ontology highlight
ABSTRACT:
SUBMITTER: Falde EJ
PROVIDER: S-EPMC4841832 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Falde Eric J EJ Freedman Jonathan D JD Herrera Victoria L M VL Yohe Stefan T ST Colson Yolonda L YL Grinstaff Mark W MW
Journal of controlled release : official journal of the Controlled Release Society 20150706
Layered superhydrophobic electrospun meshes composed of poly(ε-caprolactone) (PCL) and poly(glycerol monostearate-co-ε-caprolactone) (PGC-C18) are described as a local source of chemotherapeutic delivery. Specifically, the chemotherapeutic agent SN-38 is incorporated into a central 'core' layer, between two 'shield' layers of mesh without drug. This mesh is resistant to wetting of the surface and throughout the bulk due to the pronounced hydrophobicity imparted by the high roughness of a hydroph ...[more]