Ontology highlight
ABSTRACT:
SUBMITTER: Dieni CV
PROVIDER: S-EPMC4843000 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Dieni Cristina V CV Panichi Roberto R Aimone James B JB Kuo Chay T CT Wadiche Jacques I JI Wadiche Jacques I JI Overstreet-Wadiche Linda L
Nature communications 20160420
Persistent neurogenesis in the dentate gyrus produces immature neurons with high intrinsic excitability and low levels of inhibition that are predicted to be more broadly responsive to afferent activity than mature neurons. Mounting evidence suggests that these immature neurons are necessary for generating distinct neural representations of similar contexts, but it is unclear how broadly responsive neurons help distinguish between similar patterns of afferent activity. Here we show that stimulat ...[more]