Modeling the potential impact of vaccination on the epidemiology of congenital cytomegalovirus infection.

ABSTRACT:

Background

Understanding the potential for vaccination to change cytomegalovirus (CMV) epidemiology is important for developing CMV vaccines and designing clinical trials.

Methods

We constructed a deterministic, age-specific and time-dependent mathematical model of pathogen transmission, parameterized using CMV seroprevalence from the United States and Brazil, to predict the impact of vaccination on congenital CMV infection.

Findings

Concurrent vaccination of young children and adolescents would result in the greatest reductions in congenital CMV infections in populations with moderate and high baseline maternal seroprevalence. Such a vaccination strategy, assuming 70% vaccine efficacy, 90% coverage and 5-year duration of protection, could ultimately prevent 30-50% of

SUBMITTER: Lanzieri TM 

PROVIDER: S-EPMC4843116 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature