Ontology highlight
ABSTRACT:
SUBMITTER: Zarse K
PROVIDER: S-EPMC4844853 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Zarse Kim K Schmeisser Sebastian S Groth Marco M Priebe Steffen S Beuster Gregor G Kuhlow Doreen D Guthke Reinhard R Platzer Matthias M Kahn C Ronald CR Ristow Michael M
Cell metabolism 20120401 4
Impaired insulin and IGF-1 signaling (iIIS) in C. elegans daf-2 mutants extends life span more than 2-fold. Constitutively, iIIS increases mitochondrial activity and reduces reactive oxygen species (ROS) levels. By contrast, acute impairment of daf-2 in adult C. elegans reduces glucose uptake and transiently increases ROS. Consistent with the concept of mitohormesis, this ROS signal causes an adaptive response by inducing ROS defense enzymes (SOD, catalase), culminating in ultimately reduced ROS ...[more]