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Characterization of piRNAs across postnatal development in mouse brain.

ABSTRACT: PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues- where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.

SUBMITTER: Ghosheh Y

PROVIDER: S-EPMC4844963 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

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Characterization of piRNAs across postnatal development in mouse brain.

Ghosheh Yanal Y Seridi Loqmane L Ryu Taewoo T Takahashi Hazuki H Orlando Valerio V Carninci Piero P Ravasi Timothy T

Scientific reports 20160426

PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues- where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition ...[more]

PMID: 27112104

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