Deep brain stimulation modulates synchrony within spatially and spectrally distinct resting state networks in Parkinson's disease.

ABSTRACT: Chronic dopamine depletion in Parkinson's disease leads to progressive motor and cognitive impairment, which is associated with the emergence of characteristic patterns of synchronous oscillatory activity within cortico-basal-ganglia circuits. Deep brain stimulation of the subthalamic nucleus is an effective treatment for Parkinson's disease, but its influence on synchronous activity in cortico-basal-ganglia loops remains to be fully characterized. Here, we demonstrate that deep brain stimulation selectively suppresses certain spatially and spectrally segregated resting state subthalamic nucleus-cortical networks. To this end we used a validated and novel approach for performing simultaneous recordings of the subthalamic nucleus and cortex using magnetoencephalography (during concurrent su

SUBMITTER: Oswal A 

PROVIDER: S-EPMC4845255 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature