Unknown

Dataset Information

0

Ten-Year Outcomes of Patients With Breast Cancer With Cytologically Confirmed Axillary Lymph Node Metastases and Pathologic Complete Response After Primary Systemic Chemotherapy.


ABSTRACT: IMPORTANCE:The long-term effect of axillary pathologic complete response (pCR) on survival among women with breast cancer treated with primary systemic chemotherapy (PST) is unknown. OBJECTIVE:To assess the long-term effect of axillary pCR on relapse-free survival (RFS) and overall survival (OS) in women with breast cancer with cytologically confirmed axillary lymph node metastases treated with PST. DESIGN, SETTING, AND PARTICIPANTS:We retrospectively analyzed the effect of axillary pCR on 10-year OS and RFS among all women who received a diagnosis of breast cancer stages II to III with cytologically confirmed axillary metastases between 1989 and 2007 who received PST at a large US comprehensive cancer center. Women were stratified by post-PST axillary status, and survival outcomes were estimated and compared according to response in the breast and axilla. MAIN OUTCOMES AND MEASURES:Outcomes of interest were RFS and OS. RESULTS:Of 1600 women treated, median (range) age at diagnisis was 49 (21-86) years. A total of 454 (28.4%) achieved axillary pCR. These patients were more likely to have human epidermal growth factor receptor 2 (HER2)-positive and triple-negative disease (P?

SUBMITTER: Mougalian SS 

PROVIDER: S-EPMC4845895 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Ten-Year Outcomes of Patients With Breast Cancer With Cytologically Confirmed Axillary Lymph Node Metastases and Pathologic Complete Response After Primary Systemic Chemotherapy.

Mougalian Sarah S SS   Hernandez Mike M   Lei Xiudong X   Lynch Siobhan S   Kuerer Henry M HM   Symmans William F WF   Theriault Richard L RL   Fornage Bruno D BD   Hsu Limin L   Buchholz Thomas A TA   Sahin Aysegul A AA   Hunt Kelly K KK   Yang Wei Tse WT   Hortobagyi Gabriel N GN   Valero Vicente V  

JAMA oncology 20160401 4


<h4>Importance</h4>The long-term effect of axillary pathologic complete response (pCR) on survival among women with breast cancer treated with primary systemic chemotherapy (PST) is unknown.<h4>Objective</h4>To assess the long-term effect of axillary pCR on relapse-free survival (RFS) and overall survival (OS) in women with breast cancer with cytologically confirmed axillary lymph node metastases treated with PST.<h4>Design, setting, and participants</h4>We retrospectively analyzed the effect of  ...[more]

Similar Datasets

| S-EPMC8724774 | biostudies-literature
| S-EPMC7520755 | biostudies-literature
| S-EPMC8501060 | biostudies-literature
| S-EPMC8724374 | biostudies-literature
| S-EPMC9497171 | biostudies-literature
| S-EPMC8812621 | biostudies-literature
| S-EPMC5391061 | biostudies-literature
| S-EPMC4511091 | biostudies-literature
2019-08-20 | GSE136031 | GEO
| S-EPMC9972015 | biostudies-literature