Ontology highlight
ABSTRACT:
SUBMITTER: Yuan D
PROVIDER: S-EPMC4845953 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Yuan Dan D Shi Junfeng J Du Xuewen X Huang Yibing Y Gao Yuan Y Xu Bing B
Journal of materials chemistry. B 20160111 7
Based on the self-assembly capability of the core segment (GNNQQNY) of yeast prion Sup35, we design and synthesis a series of structurally related precursors for enzymatic formation of hydrogels. We found that, with the catalysis of alkaline phosphatase, the precursor becomes a hydrogelator that self-assembles in water to form nanofibers with an average width less than ten nanometers. Interestingly, the introduction of amyloid segment into a cytotoxic precursor (N'ffyp: D-<b>1P</b>) is able to a ...[more]