Ontology highlight
ABSTRACT:
SUBMITTER: Peixoto RT
PROVIDER: S-EPMC4846490 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Peixoto Rui T RT Wang Wengang W Croney Donyell M DM Kozorovitskiy Yevgenia Y Sabatini Bernardo L BL
Nature neuroscience 20160229 5
Some autistic individuals exhibit abnormal development of the caudate nucleus and associative cortical areas, suggesting potential dysfunction of cortico-basal ganglia (BG) circuits. Using optogenetic and electrophysiological approaches in mice, we identified a narrow postnatal period that is characterized by extensive glutamatergic synaptogenesis in striatal spiny projection neurons (SPNs) and a concomitant increase in corticostriatal circuit activity. SPNs during early development have high in ...[more]