Ontology highlight
ABSTRACT:
SUBMITTER: Cardote TA
PROVIDER: S-EPMC4848765 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Cardote Teresa A F TA Ciulli Alessio A
ChemMedChem 20151113 8
Targeting protein surfaces and protein-protein interactions (PPIs) with small molecules is a frontier goal of chemical biology and provides attractive therapeutic opportunities in drug discovery. The molecular properties of protein surfaces, including their shallow features and lack of deep binding pockets, pose significant challenges, and as a result have proved difficult to target. Peptides are ideal candidates for this mission due to their ability to closely mimic many structural features of ...[more]