Click-Crosslinked Injectable Gelatin Hydrogels.
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ABSTRACT:
SUBMITTER: Koshy ST
PROVIDER: S-EPMC4849477 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Click-Crosslinked Injectable Gelatin Hydrogels.
Koshy Sandeep T ST Desai Rajiv M RM Joly Pascal P Li Jianyu J Bagrodia Rishi K RK Lewin Sarah A SA Joshi Neel S NS Mooney David J DJ
Advanced healthcare materials 20160125 5
Injectable gelatin hydrogels formed with bioorthogonal click chemistry (ClickGel) are cell-responsive ECM mimics for in vitro and in vivo biomaterials applications. Gelatin polymers with pendant norbornene (GelN) or tetrazine (GelT) groups can quickly and spontaneously crosslink upon mixing, allowing for high viability of encapsulated cells, establishment of 3D elongated cell morphologies, and biodegradation when injected in vivo. ...[more]
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