Ontology highlight
ABSTRACT:
SUBMITTER: Vieyres G
PROVIDER: S-EPMC4849665 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Vieyres Gabrielle G Welsch Kathrin K Gerold Gisa G Gentzsch Juliane J Kahl Sina S Vondran Florian W R FW Kaderali Lars L Pietschmann Thomas T
PLoS pathogens 20160428 4
Hepatitis C virus (HCV) particles closely mimic human very-low-density lipoproteins (VLDL) to evade humoral immunity and to facilitate cell entry. However, the principles that govern HCV association with VLDL components are poorly defined. Using an siRNA screen, we identified ABHD5 (α/β hydrolase domain containing protein 5, also known as CGI-58) as a new host factor promoting both virus assembly and release. ABHD5 associated with lipid droplets and triggered their hydrolysis. Importantly, ABHD5 ...[more]