Ontology highlight
ABSTRACT:
SUBMITTER: Kulprachakarn K
PROVIDER: S-EPMC4850187 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20160216 3
Hepcidin is a peptide hormone that regulates the homeostasis of iron metabolism. The N-terminal domain of hepcidin is conserved amongst a range of species and is capable of binding Cu(II) and Ni(II) through the amino terminal copper-nickel binding motif (ATCUN). It has been suggested that the binding of copper to hepcidin may have biological relevance. In this study we have investigated the binding of Cu(II) with model peptides containing the ATCUN motif, fluorescently labelled hepcidin and hepc ...[more]